Triglyceride kinetics in fasted and fed E. coli septic rats

Conference · Mon Feb 26 04:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:6061885

Lanza-Jacoby, S; Tabares, A ^[1]

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1. Jefferson Medical Coll., Philadelphia, PA (United States)

The mechanism for the development of hypertriglyceridemia during gram-negative sepsis was studies by examining the liver production and clearance of very-low-density lipoprotein (VLDL) triglyceride (TG). To assess the liver output and peripheral clearance the kinetics of VLDL-TG were determined by a constant intravenous infusion of (2-{sup 3}H) glycerol-labeled VLDL in fasted control, fasted E. coli-treated, fed control, and fed E.coli-treated rats. Lewis inbred rats, 275-300 g, were made septic with 8 {times} 10{sup 7} live E.coli colonies per 100 g body weight. Twenty-four hours following E.coli injection serum TG of fasted E.coli-treated rats was elevated by 170% which was attributed to a 67% decrease in the clearance rate of VLDL-TG in fasted E.coli-treated rats compared with their fasted controls. The secretion of VLDL-TG declined by 31% in the livers of the fasted E.coli-treated rats which was accompanied by a 2-fold increase in the composition of liver TG. In a second series of experiments control and E.coli-treated rats were fed intragastrically (IG) a balanced solution containing glucose plus fat as the sources of nonprotein calories. Serum TG were 26% lower in the fed E.coli-treated rats because the clearance rate increased by 86%. The secretion of TG in the fed septic rats increased by 40% but this difference was not significant. In the septic rat the ability to clear triglycerides from the plasma depends upon the nutritional state.

• OSTI ID: 6061885
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 4:3
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BACTERIA
BACTERIAL DISEASES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
CLEARANCE
DIGESTIVE SYSTEM
DISEASES
ESCHERICHIA COLI
ESTERS
FASTING
GLANDS
HYDROGEN COMPOUNDS
INFECTIOUS DISEASES
INFECTIVITY
INFLAMMATION
ISOTOPE APPLICATIONS
KINETICS
LIPIDS
LIVER
MAMMALS
MATERIALS
MICROORGANISMS
NUTRITION
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RATS
REACTION KINETICS
RODENTS
SYMPTOMS
TRACER TECHNIQUES
TRIGLYCERIDES
TRITIUM COMPOUNDS
VERTEBRATES