Very-low-density lipoprotein triglyceride kinetics in acute and chronic carbohydrate-fed rats

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · Am. J. Physiol.; (United States)

OSTI ID:6746176

Hirano, T; Mamo, J; Poapst, M; Steiner, G

Very-low-density lipoprotein (VLDL)-triglyceride (TG) kinetics were examined in rats maintained on either chow and water (control) or chow and a 10% carbohydrate drinking solution (fructose or glucose). The hexose solutions were available for an acute (16 h) or chronic (14 day) period. The acute fructose (AF), acute glucose (AG), and chronic fructose (CF) groups were hypertriglyceridemic (HTG) compared with control. Plasma TG concentration in chronic glucose (CG)-fed rats was similar to control. VLDL-TG was endogenously radiolabeled in donor rats with (2-3H)-glycerol. The fractional catabolic rate (FCR) was then determined by monitoring the clearance of plasma (3H)VLDL-TG in recipient animals. Donors and recipients were treated in an identical manner. AF and CF groups had an FCR significantly lower than rats given glucose for comparable periods. Both fructose groups and the AG group also had a lower FCR than control. In contrast, FCR in the CG group was significantly higher than controls. TG production rate (TGPR) in both AF and CF fed rats did not significantly differ from controls, suggesting that the HTG observed in these animals was solely from a catabolic defect. AG- and CG-treated glucose animals both had TGPR significantly higher than controls. Therefore, overproduction of VLDL-TG contributed to the HTG associated with this carbohydrate.

• Research Organization: Univ. of Toronto, Ontario (Canada)
• OSTI ID: 6746176
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 255; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACUTE EXPOSURE
ALCOHOLS
ALDEHYDES
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARBOHYDRATES
CHRONIC EXPOSURE
DIET
ESTERS
FRUCTOSE
GLUCOSE
GLYCEROL
HEXOSES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
KINETICS
LABELLED COMPOUNDS
LIPIDS
LIPOPROTEINS
MAMMALS
METABOLISM
MONOSACCHARIDES
ORGANIC COMPOUNDS
PROTEINS
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
TRACER TECHNIQUES
TRIGLYCERIDES
TRITIUM COMPOUNDS
VERTEBRATES