Suppressor cells in transplantation tolerance: the mechanisms of tolerance in radiation chimeras

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198110000-00012· OSTI ID:6055243

Tutschka, P J; Hess, A D; Beschorner, W E; Santos, G W

Histoincompatible-complete radiation chimeras, after resolving acute graft-vs-host (GVHD), establish specific tolerance to host and donor alloantigens. This tolerance can be perturbed with immunosuppressive agents and infusions of small numbers of donor-type cells with infusions of massive numbers of donor-type cells, or with infusions of a small number of donor-type cells, that were sensitized against host antigens prior to transfer. These chimeras possess T lymphocytes in the spleen that specifically suppress donor to host mixed lymphocyte reactions and adoptively transfer suppression of GVHD to secondary hosts. Nylon-wool fractionation of chimeric spleen cells restores the response of chimeric lymphocytes to host alloantigens, suggesting that transplantation tolerance is not attributable to clonal deletion but the activity of nylon-wool-adherent T suppressor spleen cells.

• Research Organization: Johns Hopkins Univ., Baltimore, MD
• OSTI ID: 6055243
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 32:3; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560115 -- Radiation Effects on Biochemicals-- In Man-- (-1987)
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIGEN-ANTIBODY REACTIONS
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
DRUGS
EXTERNAL IRRADIATION
GRAFT-HOST REACTION
GRAFTS
IMMUNE REACTIONS
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICINE
MOSAICISM
NUCLEAR MEDICINE
RADIATION CHIMERAS
RADIOLOGY
RADIOTHERAPY
SOMATIC CELLS
SURGERY
THERAPY
TOLERANCE
TRANSPLANTS
WHOLE-BODY IRRADIATION