Suppressor cells in transplantation tolerance II. Maturation of suppressor cells in the bone marrow chimera
Histoincompatible bone marrow allografts were established in lethally irradiated rats. At various times after transplantation, the spleen cells were harvested, subjected to mixed lymphocyte cultures, and assayed for suppressor cells in vitro and in vivo by adoptive transfer studies. Alloantigen-nonspecific suppressor cells appeared in the chimera at 40 days after grafting, coinciding with the resolution of graft-versus-host disease (GVHD). At 250 days the nonspecific suppressor cells were replaced by suppressor cells specifically suppressing donor-versus-host alloantigen responses. At 720 days suppressor cells could no longer be identified by in vitro methods but were identified by in vivo adoptive transfer of transplantation tolerance. After injection of host-type antigen into chimeras, the suppressor cells could be again demonstrated by in vitro methods.
- Research Organization:
- Johns Hopkins Univ. School of Medicine, Baltimore, MD
- OSTI ID:
- 5806446
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 32:4; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Suppressor cells in transplantation tolerance: the mechanisms of tolerance in radiation chimeras
Suppressor cells in transplantation tolerance. III. The role of antigen in the maintenance of transplantation tolerance
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CESIUM COMPOUNDS
CHIMERAS
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
DATA
DIAGNOSTIC TECHNIQUES
EXPERIMENTAL DATA
GRAFT-HOST REACTION
GRAFTS
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSION
INFORMATION
IRRADIATION
LABELLED COMPOUNDS
LETHAL IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MOSAICISM
NUMERICAL DATA
ORGANS
RADIOISOTOPE SCANNING
RATS
RODENTS
SCINTISCANNING
SOMATIC CELLS
SPLEEN
TISSUES
TRANSPLANTS
TRITIUM COMPOUNDS
VERTEBRATES