Multiple tracer studies of bone uptake of /sup 99m/Tc-MDP and /sup 85/Sr

Journal Article · Mon May 01 04:00:00 EDT 1989 · Am. J. Physiol.; (United States)

OSTI ID:6025055

McCarthy, I D; Hughes, S P

Multiple tracer outflow dilution studies were performed on the normal canine tibia. In all cases /sup 125/I-labeled albumin was used as a vascular tracer. In one series of experiments /sup 99m/Tc-labeled methylene diphosphonate and (/sup 14/C)sucrose were used as test tracers, and in a second series /sup 85/Sr and /sup 22/Na were used. A bolus of three tracers was injected into the tibial nutrient artery, and fractional concentrations appearing in the ipsilateral femoral vein were measured for a period of 5 min. A distributed model, containing parameters for capillary and bone permeability and apparent volumes of distribution of interstitial fluid, was fitted to these data. It was found that there was no discrimination between movement of /sup 85/Sr or /sup 22/Na from interstitial fluid space into bone. Transcapillary exchange does not appear to be a significant barrier to exchange between blood and bone surfaces.

• Research Organization: Univ. of Edinburgh (Scotland)
• OSTI ID: 6025055
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 256; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
560162 -- Radionuclide Effects
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& Toxicology-- Animals
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BLOOD VESSELS
BODY
BODY AREAS
CAPILLARIES
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISACCHARIDES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LEGS
LIGHT NUCLEI
LIMBS
MAMMALS
METALS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PERMEABILITY
PHOSPHONATES
PROTEINS
RADIOISOTOPES
SACCHARIDES
SACCHAROSE
SKELETON
SODIUM 22
SODIUM ISOTOPES
STRONTIUM
STRONTIUM 85
STRONTIUM ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES