KINETIC STUDIES OF SKELETAL METABOLISM BY EXTERNAL COUNTING OF INJECTED RADIOISOTOPES: THE RADIOISOTOPE OSTEOGRAM

Journal Article · Wed Oct 01 04:00:00 EDT 1958 · Journal of Laboratory and Clinical Medicine (U.S.)

OSTI ID:4286794

MacDonald, N S

Methods were devised for continuously recording variations of radioactivity in bone areas with time, following injection of bone-seeking radioisotopes. These graphic records were named radioisotope osteograms. By using gamma scintillation detectors and pulse-height analyzers, it was possible to record simultaneously on separate charts the futes of two different radioisotopes following injection of a mixture. These techniques were used in rabbits to compare the clearance from blood and the accumulations in bone of Sr/ sup 85/ Na/sup 22/ and I/sup 131/ Double tracer experiments with S/sup 85/, Cr/ sup 51/-tagged erythrocytes, and I/sup 131/-labeled serum albumin elucidated certain kinetic aspects of calcium metabolism, such as vascular transport, transcapillary movemenis, ionic exchange, and bone salt accretion. Osteograms obtained after injection of Ba/sup 140/, La/sup 140/ and Sr mixtures showed that the behavior of Ba/sup 140/ is quite similar to that of Sr/sup 85/, but radically different from that of L/sup 140/. Quantitative comparisons of long-term retentions of Sr/sup 85/ and Na in various types of bone tissue were made. It was shown that information on the current metabolic status of a fracture can readily be obtained at any point during the course of healing. Osteograms showing the uptakes of Sr/sup 85/ and Na/sup 24/- or I/sup 131/-labeled serum albumin during the first hour after their injection, followed by daily monitoring of the bone areas, provide the necessary data. Extension of the techniques to the study and diagnosis of metabolic disorders and lesions of the human skeleton is discussed. (auth)

• Research Organization: Univ. of California, Los Angeles
• NSA Number: NSA-13-003539
• OSTI ID: 4286794
• Journal Information: Journal of Laboratory and Clinical Medicine (U.S.), Journal Name: Journal of Laboratory and Clinical Medicine (U.S.) Vol. Vol: 52; ISSN JLCMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALBUMINS-- BARIUM 140-- BLOOD SERUM-- BLOOD VESSELS-- CALCIUM-- CHROMIUM 51-- DIAGNOSIS-- DISEASES-- ERYTHROCYTES-- ION EXCHANGE-- LABELLED COMPOUNDS-- LANTHANUM 140-- MAN-- RADIOAUTOGRAPHY-- SALTS
BIOLOGY AND MEDICINE
BLOOD-- BONES-- GAMMA DETECTION-- IODINE 131-- METABOLISM-- PULSE ANALYZERS-- RABBITS-- SCINTILLATION COUNTERS-- SODIUM 22-- STRONTIUM 85-- TRACER TECHNIQUES