Exchange of potassium and strontium in adult bone. [Dogs]

Journal Article · Thu Apr 01 04:00:00 EST 1982 · Am. J. Physiol.; (United States)

OSTI ID:5172863

Maltby, B; Lemon, G J; Bassingthwaighte, J B; Kelly, P J

The kinetics of exchange of strontium (/sup 85/Sr) and potassium (/sup 42/K) were studied in the midtibial cortical bone of 37 adult dogs. After injection of these two tracer cations and tracer-labeled albumin into the tibial nutrient artery, two types of observations were made: 1) collection of sequential venous samples to provide the outflow indicator-dilution curves and to calculate the extraction and retention at early times; and 2) detection of energy-selected gamma emissions via a detector over the tibia to give the time course of content of /sup 42/K and /sup 85/Sr in the tibia. Extractions of K/sup +/ and Sr/sup 2 +/ were 50 and 60% during a single transcapillary passage. More Sr/sup 2 +/ than K/sup +/ was retained in the first minutes. Their rates of washout over a 3-h period were similar. The interpretation is that the rate of uptake at extravascular sites is faster for Sr/sup 2 +/ than for K/sup +/, as is the rate of release, and that the extravascular volume of distribution for Sr/sup 2 +/ (adsorption sites in the interstitium or on bone) is much larger than that for K/sup +/ (intracellular).

• Research Organization: Mayo Clinic, Rochester, MN
• OSTI ID: 5172863
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 242:4; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE SEEKERS
CHEMICAL ANALYSIS
DAYS LIVING RADIOISOTOPES
DETECTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GAMMA DETECTION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ION EXCHANGE
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
POTASSIUM 42
POTASSIUM ISOTOPES
PROTEINS
QUANTITATIVE CHEMICAL ANALYSIS
RADIATION DETECTION
RADIOCHEMICAL ANALYSIS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION FUNCTIONS
SKELETON
STRONTIUM 85
STRONTIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES