Uric acid protects erythrocytes from ozone-induced changes

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(87)80041-5· OSTI ID:6018749

Meadows, J; Smith, R C

Uric acid effectively reduced hemolysis and methemoglobin formation in bovine and swine erythrocytes bubbled with ozone in vitro. In bovine erythrocytes, formation of thiobarbituric acid-reactive material was inhibited by uric acid, but there was little immediate protection for the swine cells. Antioxidant protection was due to preferential degradation of the uric acid by ozone. These results provide evidence to support the hypothesis that in plasma, uric acid can provide antioxidant protection for erythrocytes.

• Research Organization: Auburn Univ., AL
• OSTI ID: 6018749
• Journal Information: Environ. Res.; (United States), Vol. 43:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OZONE
TOXICITY
URIC ACID
BIOLOGICAL EFFECTS
CATTLE
ERYTHROCYTES
HEMOLYSIS
IN VITRO
METHEMOGLOBIN
SWINE
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
DOMESTIC ANIMALS
GLOBIN
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LYSIS
MAMMALS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PIGMENTS
PORPHYRINS
PROTEINS
PURINES
RUMINANTS
VERTEBRATES
XANTHINES
560300* - Chemicals Metabolism & Toxicology