Uric acid protects membranes and linolenic acid from ozone-induced oxidation
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Aqueous preparations of linolenic acid, bovine serum albumin, and bovine erythrocyte membrane fragments were bubbled with ozone in the presence or absence of uric acid. Ozonation of the membrane fragments or the bovine serum albumin did not result in protein degradation. After 15 min of ozonation, the absorbance of the thiobarbituric acid-reactive material increased by 0.34 in the linolenic acid preparation and by 0.08 in the suspension of membrane fragments. In the presence of uric acid, these changes in absorbance were reduced to 0.14 for the fatty acid and to 0.01 for the membrane fragments. This result indicates that uric acid protects lipids from ozone-induced oxidation.
- Research Organization:
- Auburn Univ., AL
- OSTI ID:
- 5268521
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 1; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL EFFECTS
CATTLE
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL REACTIONS
DOMESTIC ANIMALS
HETEROCYCLIC COMPOUNDS
LIPIDS
MAMMALS
MEMBRANES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXIDATION
OZONE
PURINES
RESPONSE MODIFYING FACTORS
RUMINANTS
URIC ACID
VERTEBRATES
XANTHINES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL EFFECTS
CATTLE
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL REACTIONS
DOMESTIC ANIMALS
HETEROCYCLIC COMPOUNDS
LIPIDS
MAMMALS
MEMBRANES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXIDATION
OZONE
PURINES
RESPONSE MODIFYING FACTORS
RUMINANTS
URIC ACID
VERTEBRATES
XANTHINES