Uric acid protection of nucleobases from ozone-induced degradation

Journal Article · Thu May 01 04:00:00 EDT 1986 · Arch. Biochem. Biophys.; (United States)

DOI:https://doi.org/10.1016/0003-9861(86)90340-1· OSTI ID:5686930

Meadows, J; Smith, R C

Uric acid has been proposed to be an important antioxidant and free radical scavenger in humans. Of the purine and pyrimidine compounds examined in this study, uric acid showed the greatest susceptibility to ozone-induced degradation. The parent compounds, purine and pyrimidine, were more resistant to ozonation than were the nucleobases. When the degradation of OH-substituted purines was examined, it was found that the more OH groups on the purine ring, the more readily the purine was degraded. Urea and allantoin were identified as degradation products of uric acid. The relative rates of nucleobase degradation in the presence and absence of uric acid were compared. Uric acid protected thymine, guanine, and uracil from degradation by ozone. In this system uric acid was found to protect the nucleobases as effectively as reduced glutathione.

• Research Organization: Auburn Univ, AL
• OSTI ID: 5686930
• Journal Information: Arch. Biochem. Biophys.; (United States), Journal Name: Arch. Biochem. Biophys.; (United States) Vol. 2; ISSN ABBIA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANTIOXIDANTS
AROMATICS
AZAARENES
AZINES
BIOLOGICAL EFFECTS
CHEMICAL REACTIONS
GUANINE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OZONE
OZONIZATION
PURINES
PYRIMIDINES
THYMINE
TOXICITY
URACILS
URIC ACID
XANTHINES