Comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non-Hodgkin's lymphoma. [Effectiveness and complications]

Journal Article · Fri Jun 01 00:00:00 EDT 1979 · Cancer; (United States)

OSTI ID:6000529

Brereton, H D; Young, R C; Longo, D L; Kirkland, L R; Berard, C W; Jaffe, E S; DeVita, V T; Johnson, R E

Thirty-nine untreated patients with either lymphocytic or nodular mixed/nodular histiocytic non-Hodgkin's lymphoma, stage II-IV, were randomized to treatment with total body irradiation (TBI), 100 rads in 10 fractions over 12 days, plus combination chemotherapy with either cyclophosphamide, vincristine and prednisone (CVP) or cyclophosphamide, vincristine, procarbazine and prednisone (C-MOPP) or to treatment with combination chemotherapy (CVP or C-MOPP) alone. Remission rate and duration were comparable for both treatment groups; thus the use of both treatment modalities ab initio provides no therapeutic advantage.

• Research Organization: National Cancer Inst., Bethesda, MD
• OSTI ID: 6000529
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 43:6; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
550900 -- Pathology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMOTHERAPY
DATA
DATA FORMS
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DRUGS
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FISTULAE
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
GLOBIN
HEMIC DISEASES
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
INFLAMMATION
INFORMATION
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LARGE INTESTINE
LEUKOCYTES
LEUKOPENIA
LOW DOSE IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PIGMENTS
PORPHYRINS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RECTUM
SIDE EFFECTS
SYMPTOMS
THERAPY
WHOLE-BODY IRRADIATION