Combination chemotherapy of lymphomas other than Hodgkin's disease. [Vincristine, prednisone, cyclophosphamide, procarbazine]
Journal Article
·
· Ann. Intern. Med.; (United States)
The efficacy and toxicity of two regimens of combination chemotherapy were compared in patients with lymphoma, other than Hodgkin's disease, in pathologic stage IV. Patients were assigned by unrestricted randomization to receive either vincristine and prednisone or cyclophosphamide, vincristine, procarbazine, and prednisone (COPP). Patients who didn't have complete remission on vincristine and prednisone were switched to COPP. In the randomized trial COPP was superior to vincristine and prednisone, in the rates of induction of complete remission, which were 58% and 14%, respectively (P < 0.005). Of 32 patients receiving COPP, the rate of induction of complete remission was 59% and the median length of complete remission was greater than 18 months. COPP produced a complete remission in 18 of 26 patients with lymphoma other than histiocytic lymphoma. These results compare favorably with those of previously reported regimens. The value of COPP in patients with lymphoma seems to have been shown.
- Research Organization:
- Univ. of Chicago
- OSTI ID:
- 5276418
- Journal Information:
- Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 81:5; ISSN AIMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non-Hodgkin's lymphoma. [Effectiveness and complications]
Combined modality therapy of diffuse histology non-Hodgkin's lymphoma with cyclophosphamide, adriamycin, vincristine, prednisone (CHOP) and total body irradiation
Total body irradiation and cyclophosphamide, vincristine, prednisone in the treatment of favorable prognosis non-Hodgkin's lymphomas
Journal Article
·
Fri Jun 01 00:00:00 EDT 1979
· Cancer; (United States)
·
OSTI ID:6000529
Combined modality therapy of diffuse histology non-Hodgkin's lymphoma with cyclophosphamide, adriamycin, vincristine, prednisone (CHOP) and total body irradiation
Journal Article
·
Mon Aug 01 00:00:00 EDT 1983
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5744964
Total body irradiation and cyclophosphamide, vincristine, prednisone in the treatment of favorable prognosis non-Hodgkin's lymphomas
Conference
·
Sat Sep 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5236784