Combined modality therapy of diffuse histology non-Hodgkin's lymphoma with cyclophosphamide, adriamycin, vincristine, prednisone (CHOP) and total body irradiation

Journal Article · Mon Aug 01 04:00:00 EDT 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90181-5· OSTI ID:5744964

Weick, J K ^[1]; Antunez, A; Kraus, T A; Fabian, C J; Dixon, D

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1. Cleveland Clinic, OH

The combination of cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) alternating with total body irradiation (TBI) has been shown earlier to be effective therapy in patients with malignant lymphoma who have received prior chemotherapy and/or radiation therapy. A limited institutional pilot study was therefore done by the Southwest Oncology Group between October 1977, and November 1978 to test the benefit of this program in previously untreated persons with Stages 3 and 4 diffuse histology non-Hodgkin's lymphoma. Eleven evaluable patients with the following histologies were treated: 7 poorly differentiated, 2 with histiocytic, 1 with mixed lymphoma and 1 with well-differentiated morphology. Responses were seen in 8/11 patients (6 CR and 2 PR); 5 persons are currently alive and 6 are dead. The median duration of remission is 15 months and the median survival for all patients is 48 months. The therapy was well tolerated with a mean nadir leukocyte count of 3020 x 10/sup 9//..mu..l (range 1.2 to 5.5) and a mean nadir platelet count of 188 x 10/sup 9//..mu..l (range 016 to 270). As delivered, this program is capable of producing durable remissions and needs to be verified in a larger series of patients.

• OSTI ID: 5744964
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 9:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKALOIDS
ALKYLATING AGENTS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
CHEMOTHERAPY
CORTICOSTEROIDS
DISEASES
DOXORUBICIN
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
EXTERNAL IRRADIATION
GLUCOCORTICOIDS
HARD X RADIATION
HORMONES
HYDROXY COMPOUNDS
IMMUNOSUPPRESSION
IMMUNOSUPPRESSIVE DRUGS
IONIZING RADIATIONS
IRRADIATION
KETONES
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ONCOVIN
ORGANIC COMPOUNDS
PATIENTS
PREDNISONE
PREGNANES
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
STEROID HORMONES
STEROIDS
THERAPY
WHOLE-BODY IRRADIATION
X RADIATION