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Total body irradiation and cyclophosphamide, vincristine, prednisone in the treatment of favorable prognosis non-Hodgkin's lymphomas

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5236784
; ; ; ; ;

A pilot study was undertaken to test the feasibility of administering total body irradiation (TBI) followed by chemotherapy with cyclophosphamide, vincristine and prednisone (CVP). Twelve patients with previously untreated Stages III to IV non-Hodgkin's lymphoma were studied. Nine patients had nodular poorly differentiated lymphocytic lymphoma and 3 had nodular mixed lymphoma. TBI was given to a total dose of 150 rad in biweekly 15 rad fractions. Reversible thrombocytopenia and neutropenia were observed and resulted in 3 attenuated courses (105 rad, 120 rad, 135 rad). No bleeding, infection or other important toxicity occurred from TBI. After a median of 45 days following TBI, all patients began CVP. Eleven patients completed 6 cycles; 1 patient refused further chemotherapy after the first cycle. Dosage adjustments made for neutropenia and thrombocytopenia were such that 83% of the planned cyclophosphamide dose was given. No bleeding, serious infections or fatalities were seen. Toxicities included parathesias, nausea and abdominal pain. At the end of chemotherapy, 6 of the 11 patients who completed 6 cycles of CVP were disease free with remissions of 3+, 4+, 7+, 11+, 14 and 20+ months. TRI + CVP delivered in the manner described is associated with acceptable toxicity.

Research Organization:
Univ. of Iowa, Iowa City
OSTI ID:
5236784
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:9; ISSN IOBPD
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKALOIDS
ALKYLATING AGENTS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CHEMOTHERAPY
CORTICOSTEROIDS
DISEASES
DOSES
DRUGS
ENDOXAN
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GLUCOCORTICOIDS
HEMIC DISEASES
HORMONES
HYDROXY COMPOUNDS
IRRADIATION
KETONES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MATERIALS
NEOPLASMS
ONCOVIN
ORGANIC COMPOUNDS
PATIENTS
PREDNISONE
PREGNANES
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
SIDE EFFECTS
STEROID HORMONES
STEROIDS
THERAPY
TOXICITY
WHOLE-BODY IRRADIATION