Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Total body irradiation in non-Hodgkin's lymphoma. [Efficacy and complications]

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
; ;
Between October 1972 and August 1977, low-dose fractionated total body irradiation (TBI), 150 to 300 rad,, was selected for 48 patients with previously untreated non-Hodgkin's lumphoma staged II, III, and IV. In 63% of the patients the disease had a nodular pattern; there were no patients with diffuse histiocytic lymphoma. All but 2 patients responded to TBI. The 4-year acutarial survival was 71% for the nodular group and 57% for the diffuse group. There were no acute symptoms during the course of treatment and no mortality associated with the treatment. Seventeen per cent of the patients developed transient platelet counts less than 30,000/mm/sup 3/. Four required hospitilization for correction of thrombocytopenia and/or infection. The majority of patients who failed more than 3 months after initial complete remission were placed back in remission with either chemotherapy, TBI, or local irradiation. Patients with persistent disease after TBI showed a less favorable response with chemotherapy. A selected group of 15 patients in relapse after chemotherapy or localized radiotherapy were treated with TBI. Eleven responded to treatment, while 4 showed no useful response. The median survival for this group was slightly over 2 years. Twenty percent developed transient platelet counts less than 30,000/mm/sup 3/.
Research Organization:
Univ. of Florida, Gainesville
OSTI ID:
5408200
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:2; ISSN IOBPD
Country of Publication:
United States
Language:
English

Similar Records

Low-dose fractionated whole-body irradiation in the treatment of advanced non-Hodgkin's lymphoma. [Effectiveness and complications]
Journal Article · Tue May 01 00:00:00 EDT 1979 · Cancer; (United States) · OSTI ID:6000357
Comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non-Hodgkin's lymphoma. [Effectiveness and complications]
Journal Article · Fri Jun 01 00:00:00 EDT 1979 · Cancer; (United States) · OSTI ID:6000529
Total body irradiation and cyclophosphamide, vincristine, prednisone in the treatment of favorable prognosis non-Hodgkin's lymphomas
Conference · Sat Sep 01 00:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5236784

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
550900 -- Pathology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
COBALT 60
COBALT ISOTOPES
DATA
DATA FORMS
DISEASES
DOSE RATES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GAMMA RADIATION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOW DOSE IRRADIATION
LYMPHOMAS
MATERIALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES