Transferrin-mediated uptake of gallium-67 by EMT-6 sarcoma. II. Studies in vivo (BALB/c mice). Concise communication
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5998800
The EMT-6 sarcoma-like tumor of BALB/c mice can be grown as a solid subcutaneous transplantable tumor in vivo or as a monolayer culture in vitro. We have studied the uptake of gallium-67 by this tumor growing subcutaneously on the backs of 6-week-old BALB/c mice. After i.v. administration of Ga-67 citrate, tumor uptakes were as high as any others reported for mouse tumors. Also, for unknown reasons, there was appreciable reduction in tumor uptake with increasing amounts of Ga-67 citrate, even in the microcurie range. Furthermore, when mouse serum is prelabeled with Ga-67 and then injected, the EMT-6 uptake is greater than with Ga-67 administered as citrate (p < 0.02). We believe that the finding of avid Ga-67 uptake in vivo helps to establish this unique in vivo/in vitro tumor system as a valid experimental model for studies regarding the mechanism of Ga-67 accumulation by neoplastic tissue.
- Research Organization:
- Veterans Administration Hospital, Seattle, WA
- OSTI ID:
- 5998800
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:8; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Transferrin-mediated uptake of gallium-67 by EMT-6 sarcoma. I. Studies in tissue culture
Journal Article
·
Sun Dec 31 23:00:00 EST 1978
· Radiology; (United States)
·
OSTI ID:6591158
Common pathway for tumor cell uptake of gallium-67 and iron-59 via a transferrin receptor
Journal Article
·
Mon Dec 31 23:00:00 EST 1979
· J. Natl. Cancer Inst.; (United States)
·
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Transferrin-mediated uptake of gallium-67 by EMT-6 sarcoma. I. Studies in tissue culture
Journal Article
·
Wed Aug 01 00:00:00 EDT 1979
· J. Nucl. Med.; (United States)
·
OSTI ID:6137787
Related Subjects
550301 -- Cytology-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD SERUM
CARBOXYLIC ACID SALTS
CITRATES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
GALLIUM 67
GALLIUM ISOTOPES
IN VIVO
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIOISOTOPES
RODENTS
SARCOMAS
TUMOR CELLS
UPTAKE
VERTEBRATES
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD SERUM
CARBOXYLIC ACID SALTS
CITRATES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
GALLIUM 67
GALLIUM ISOTOPES
IN VIVO
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIOISOTOPES
RODENTS
SARCOMAS
TUMOR CELLS
UPTAKE
VERTEBRATES