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Pharmacologic enhancement of gallium-67 tumor-to-blood ratios for EMT-6 sarcoma (BALB/c mice)

Journal Article · · Radiology; (United States)
DOI:https://doi.org/10.1148/130.1.241· OSTI ID:6591158
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At various intervals after intravenous injection of carrier-free /sup 67/Ga-citrate, iron dextran or deferoxamine mesylate was injected into EMT-6 tumor-bearing BALB/c mice. After treatment, rapid clearance of /sup 67/Ga from soft tissues was observed. Tumor uptake was not greatly affected, and so increased tumor-to-blood ratios were observed. The authors conclude that these drugs can enhance target-to-nontarget uptake ratios for tumors.
Research Organization:
Veterans Administration Hospital, Seattle, WA
OSTI ID:
6591158
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 130:1; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BLOOD SUBSTITUTES
BODY
CARBOHYDRATES
CARBOXYLIC ACID SALTS
CHELATING AGENTS
CITRATES
CLEARANCE
COMPLEXES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DEFEROXAMINE
DEXTRAN
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL NEOPLASMS
GALLIUM 67
GALLIUM COMPOUNDS
GALLIUM ISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
IRON COMPLEXES
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
POLYSACCHARIDES
QUANTITY RATIO
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SACCHARIDES
SARCOMAS
SCINTISCANNING
TISSUES
TRANSITION ELEMENT COMPLEXES
VERTEBRATES