Desferal (DFO) induced Ga-67 washout from normal tissue, tumor and abscess in experimental animals

Conference · Tue Jan 01 04:00:00 EST 1980

OSTI ID:6880111

Oster, Z H; Som, P; Atkins, H L; Brill, A B

In the experimental animal, desferal (DFO) given intravenously washes out Ga-67 from all tissues. This effect is not uniform: blood activity is reduced very markedly, while liver activity is less affected. Maximal effect of DFO occurs if given close to the Ga-67 injection. When the time interval between the two is increased, the absolute amount of Ga-67 excreted in the urine in excess of the spontaneous excretion is reduced. Administration of DFO does not effect Ga-67 gastrointestinal excretion. In three animal tumor models (EMT-6 sarcoma in Balb/c mice, spontaneous adenocarcinoma in mice, and spontaneous adenocarcinoma in the rabbit) and in sterile abscess-bearing rats, the administration of DFO 24 hrs after Ga-67-citrate improves significantly the target-to-nontarget ratio. Animals given 50 mg/kg DFO I.V. after Ga-67 citrate showed a significant reduction in the whole-body activity as seen in a one-week follow up.

• Research Organization: Brookhaven National Lab., Upton, NY (USA); State Univ. of New York, Stony Brook (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6880111
• Report Number(s): BNL-28487; CONF-801082-3
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSCESSES
AMINES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CARCINOMAS
CHELATING AGENTS
CITRATES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DEFEROXAMINE
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
GALLIUM 67
GALLIUM ISOTOPES
INFLAMMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRECIPITATION SCAVENGING
RABBITS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RODENTS
SARCOMAS
SEPARATION PROCESSES
TISSUES
TUMOR CELLS
URINE
VERTEBRATES
WASHOUT
WASTES