Different actions of deferoxamine and iron on Ga-67 abscess detection in rats

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · J. Nucl. Med.; (United States)

OSTI ID:6982946

Oberhensli, R D; Mueller, R M; Fridrich, R

The contrast-enhancing properties of iron (Fe) and deferoxamine (DFO) in abscess imaging with Ga-67 citrate were compared in rats bearing turpentine-induced abscesses. Iron administration shifted Ga-67 from plasma into tissues such as muscle and fat. As a result, the abscess-to-plasma ratio increased whereas the abscess-to-muscle ratio decreased. DFO enhanced the abscess-to-muscle and abscess-to-plasma ratios by increasing urinary Ga-67 excretion. The authors conclude that abscess imaging with Ga-67 citrate may be improved by administration of (a) Fe for detection of abscesses masked by blood activity, or (b) DFO for detection of abscesses surrounded by muscle tissue.

• Research Organization: Univ. Hospital, Basel, Switzerland
• OSTI ID: 6982946
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSCESSES
ADIPOSE TISSUE
AMINES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CHELATING AGENTS
CITRATES
CONNECTIVE TISSUE
DATA
DAYS LIVING RADIOISOTOPES
DEFEROXAMINE
DIAGNOSIS
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EXPERIMENTAL DATA
GALLIUM 67
GALLIUM ISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
IRON
ISOTOPES
MAMMALS
MATERIALS
METALS
MUSCLES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RATS
RODENTS
TISSUE DISTRIBUTION
TISSUES
TRANSITION ELEMENTS
VERTEBRATES