Inhibition of host protein synthesis and degradation of cellular mRNAs during infection by influenza and herpes simplex virus

Journal Article · Wed Dec 01 00:00:00 EST 1982 · Mol. Cell. Biol.; (United States)

DOI:https://doi.org/10.1128/MCB.2.12.1644· OSTI ID:5996599

Inglis, S C

Cloned DNA copies of two cellular genes were used to monitor, by blot hybridization, the stability of particular cell mRNAs after infection by influenza virus and herpes virus. The results indicated that the inhibition of host cell protein synthesis that accompanied infection by each virus could be explained by a reduction in the amounts of cellular mRN As in the cytoplasm, and they suggested that this decrease was due to virus-mediated mRNA degradation.

• Research Organization: Div. of Virology, Dept. of Pathology, Univ. of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ
• OSTI ID: 5996599
• Journal Information: Mol. Cell. Biol.; (United States), Vol. 2:12
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CELL TRANSFORMATIONS
MOLECULAR BIOLOGY
HERPES SIMPLEX
HOST-CELL REACTIVATION
INFECTIVITY
INFLUENZA VIRUSES
MESSENGER-RNA
GENE REPRESSORS
RNA-ASE
GENES
BIODEGRADATION
HYBRIDIZATION
PROTEINS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL REACTIONS
DECOMPOSITION
DISEASES
ENZYMES
ESTERASES
HYDROLASES
INFECTIOUS DISEASES
MICROORGANISMS
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PARASITES
PHOSPHODIESTERASES
RECOVERY
REPAIR
RNA
SKIN DISEASES
VIRAL DISEASES
VIRUSES
550400* - Genetics