Inhibition of host protein synthesis and degradation of cellular mRNAs during infection by influenza and herpes simplex virus
Journal Article
·
· Mol. Cell. Biol.; (United States)
Cloned DNA copies of two cellular genes were used to monitor, by blot hybridization, the stability of particular cell mRNAs after infection by influenza virus and herpes virus. The results indicated that the inhibition of host cell protein synthesis that accompanied infection by each virus could be explained by a reduction in the amounts of cellular mRN As in the cytoplasm, and they suggested that this decrease was due to virus-mediated mRNA degradation.
- Research Organization:
- Div. of Virology, Dept. of Pathology, Univ. of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ
- OSTI ID:
- 5996599
- Journal Information:
- Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 2:12; ISSN MCEBD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIODEGRADATION
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL TRANSFORMATIONS
CHEMICAL REACTIONS
DECOMPOSITION
DISEASES
ENZYMES
ESTERASES
GENE REPRESSORS
GENES
HERPES SIMPLEX
HOST-CELL REACTIVATION
HYBRIDIZATION
HYDROLASES
INFECTIOUS DISEASES
INFECTIVITY
INFLUENZA VIRUSES
MESSENGER-RNA
MICROORGANISMS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PARASITES
PHOSPHODIESTERASES
PROTEINS
RECOVERY
REPAIR
RNA
RNA-ASE
SKIN DISEASES
VIRAL DISEASES
VIRUSES
59 BASIC BIOLOGICAL SCIENCES
BIODEGRADATION
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL TRANSFORMATIONS
CHEMICAL REACTIONS
DECOMPOSITION
DISEASES
ENZYMES
ESTERASES
GENE REPRESSORS
GENES
HERPES SIMPLEX
HOST-CELL REACTIVATION
HYBRIDIZATION
HYDROLASES
INFECTIOUS DISEASES
INFECTIVITY
INFLUENZA VIRUSES
MESSENGER-RNA
MICROORGANISMS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PARASITES
PHOSPHODIESTERASES
PROTEINS
RECOVERY
REPAIR
RNA
RNA-ASE
SKIN DISEASES
VIRAL DISEASES
VIRUSES