Proteins associated with mRNA in cells infected with herpes simplex virus

Journal Article · Mon Oct 16 04:00:00 EDT 1989 · Biochemical and Biophysical Research Communications; (USA)

DOI:https://doi.org/10.1016/0006-291X(89)91726-9· OSTI ID:5155907

Krikorian, C R; Read, G S ^[1]

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1. Loyola Univ. of Chicago, IL (USA)

The structure of messenger ribonucleoprotein (mRNP) complexes in herpes simplex virus type 1 (HSV-1) infected cells was analyzed by examining the proteins that could be crosslinked to polyadenylated mRNAs by irradiation of intact cells with ultraviolet light. The profiles of crosslinked proteins were qualitatively similar for mRNPs from mock infected and infected cells. However, infection with wild type HSV-1 caused a decrease in the abundance of a major 52 kda protein and an increase in a 49 kda protein. These changes were observed at early times after infection. They occurred following infection with wild type HSV-1 under conditions that blocked viral gene expression, but not following infection with the virion host shutoff mutant vhs 1.

• OSTI ID: 5155907
• Journal Information: Biochemical and Biophysical Research Communications; (USA), Journal Name: Biochemical and Biophysical Research Communications; (USA) Vol. 164:1; ISSN BBRCA; ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

560130* -- Radiation Effects on Microorganisms
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CROSS-LINKING
DISEASES
ELECTROMAGNETIC RADIATION
ELECTROPHORESIS
GENE REGULATION
HELA CELLS
HERPES SIMPLEX
INFECTIOUS DISEASES
MESSENGER-RNA
MICROORGANISMS
MOLECULAR STRUCTURE
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PARASITES
POLYMERIZATION
PROTEINS
RADIATION EFFECTS
RADIATIONS
REAGENTS
RNA
SKIN DISEASES
ULTRAVIOLET RADIATION
VIRAL DISEASES
VIRUSES