Dissociation of changes in the permeability of the blood-brain barrier from catecholamine-induced changes in blood pressure of normotensive and spontaneously hypertensive rats

Journal Article · Wed Sep 01 04:00:00 EDT 1982 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:5993979

Sankar, R; Domer, F R; Taylor, B

Researchers have studied the effects of the pressor catecholamine, dopamine, and the depressor catecholamine, isoproterenol, on the systemic blood pressure and the permeability of the blood-brain barrier (BBB) to albumin in normotensive (WKY) and spontaneously hypertensive (SHR) rats. The rats were anesthetized with pentobarbital. The permeability of the BBB to protein was measured by the extravasation of radioiodinated serum albumin (RISA). The permeability was decreased by both catecholamines despite the dose-dependent, yet opposite, changes in blood pressure in the WKY rats. The blood pressure response to both of the catecholamines was enhanced in the SHR rats. Isoproterenol caused a decrease in the permeability of the BBB in the SHR but dopamine did not. Results with both WKY and SHR rats are suggestive of an adrenergically-mediated decrease in movement across the BBB of compounds of large molecular weight, regardless of changes in blood pressure.

• Research Organization: Tulane University School of Medicine, New Orleans, Louisiana
• OSTI ID: 5993979
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 37:3; ISSN RCOCB
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
AMINES
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
BLOOD-BRAIN BARRIER
CARDIOVASCULAR DISEASES
CATECHOLAMINES
DISEASES
HYDROXY COMPOUNDS
HYPERTENSION
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
NORTH AMERICA
ORGANIC COMPOUNDS
PERMEABILITY
PHENOLS
POLYPHENOLS
PROTEINS
QUANTITY RATIO
RATS
RODENTS
SYMPTOMS
TRACER TECHNIQUES
USA
VASCULAR DISEASES
VERTEBRATES