Cold-restraint induced gastric lesions in normotensive and spontaneously hypertensive rats
Journal Article
·
· Life Sci.; (United States)
Spontaneously hypertensive (SHR) rats and normotensive Wistar-Kyoto (WKY) rats were subjected to 2 hr of cold-restraint stress at 4-6/sup o/C following a 24 hr fast. WKY rats had a significantly greater incidence and degree of ulceration of the gastric glandular mucosa than did SHR rats. Mean arterial pressure, obtained from a chronic arterial cannula, fell during 2 hr of cold-restraint stress in both SHR and WKY rats. Heart rate was unchanged in WKY but fell significantly in SHR. Plasma norepinephrine (NE) and epinephrine (E), determined by radioenzymatic assay, increased significantly following stress. Increased levels of NE remained similar for both SHR and WKY rats, while post-stress levels of E for the SHR rats greatly exceeded E levels for WKY rats. A greater degree of hypothermia was also noted in SHR rats. Decreased stress induced ulcerogenesis in the SHR may be due to the well-known altered hemodynamic and autonomic nervous system reactivity in this strain or other factors not yet discovered.
- Research Organization:
- East Carolina Univ., Greenville, NC
- OSTI ID:
- 5705583
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 28:8; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560205* -- Thermal Effects-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY TEMPERATURE
CARDIOVASCULAR DISEASES
COMPARATIVE EVALUATIONS
DATA
DIGESTIVE SYSTEM
DISEASES
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
HYPERTENSION
HYPOTENSION
HYPOTHERMIA
INFORMATION
MAMMALS
NUMERICAL DATA
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
RATS
RODENTS
SPECIES DIVERSITY
STOMACH
SYMPTOMS
ULCERS
VASCULAR DISEASES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY TEMPERATURE
CARDIOVASCULAR DISEASES
COMPARATIVE EVALUATIONS
DATA
DIGESTIVE SYSTEM
DISEASES
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
HYPERTENSION
HYPOTENSION
HYPOTHERMIA
INFORMATION
MAMMALS
NUMERICAL DATA
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
RATS
RODENTS
SPECIES DIVERSITY
STOMACH
SYMPTOMS
ULCERS
VASCULAR DISEASES
VERTEBRATES