Effects of acute catecholamine depletion on cardiac function in normotensive and spontaneously hypertensive rats
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5506418
Reserpine(6mg/Kg) was injected IP in Wistar (n = 5, age 10 wks.) and spontaneously hypertensive (SHR) rats (n = 5, age 16 wks.). After 4 hours the hearts were isolated (Langendorff), perfused with Krebs-Henseleit solution and paced at 240/min. Non-injected Wistar (N = 5) and SHR (n = 6) rats were used for controls. Myocardial levels of norepinephrine (NE) and epinephrine (E) were determined with radioenzymatic assay. Left ventricular systolic and distolic pressures were recorded for left ventricular end diastolic volumes (LVEDV) .05 to .40 ml. Despite a marked decrease in tissue levels of NE and E, peak systolic pressure (PSP) increased in reserpine treated normotensive and SHR rats. In isolated control SHR rat hearts (LVEDV = .20 ml), PSP was related to NE by PSP = .0145 (NE) + 93 (r = .819, p < .01). In conclusion, cardiac performance and tissue levels of myocardial catecholamines are correlated in control rats. However, rapid depletion of myocardial catecholamines may result in increased cardiac performance.
- Research Organization:
- Akron City Hospital, OH
- OSTI ID:
- 5506418
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATECHOLAMINES
DISEASES
DRUGS
HEART
HORMONES
HYDROXY COMPOUNDS
HYPERTENSION
MAMMALS
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PERFUSED ORGANS
PHENOLS
POLYPHENOLS
RADIOENZYMATIC ASSAY
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATECHOLAMINES
DISEASES
DRUGS
HEART
HORMONES
HYDROXY COMPOUNDS
HYPERTENSION
MAMMALS
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PERFUSED ORGANS
PHENOLS
POLYPHENOLS
RADIOENZYMATIC ASSAY
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES