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Impromidine-induced changes in the permeability of the blood-brain barrier of normotensive and spontaneously hypertensive rats

Journal Article · · Research Communications in Chemical Pathology and Pharmacology; (USA)
OSTI ID:6420391
; ;  [1]
  1. Southern Univ. at New Orleans, LA (USA)
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Previous studies suggested histamine receptors mediate changes in the cerebrovascular permeability of rats. To test this, we investigated the effects of impromidine, a specific agonist at the histamine H2-receptor, on blood pressure and permeability of the blood-brain barrier (BBB). Impromidine produced dose-dependent hypotension in Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Two higher doses of impromidine increased BBB permeability to 99mTc-sodium pertechnetate in WKY rats; however, two lower doses decreased permeability in SHR rats. All doses of impromidine increased cerebrovascular permeability to 131I-labeled serum albumin in both species. Doses of the drug were 100 times greater than those required to produce similar alterations using histamine.
OSTI ID:
6420391
Journal Information:
Research Communications in Chemical Pathology and Pharmacology; (USA), Journal Name: Research Communications in Chemical Pathology and Pharmacology; (USA) Vol. 69:2; ISSN 0034-5164; ISSN RCOCB
Country of Publication:
United States
Language:
English

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Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
ALKALI METAL COMPOUNDS
AMINES
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BLOOD PRESSURE
BLOOD-BRAIN BARRIER
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
HETEROCYCLIC COMPOUNDS
HISTAMINE
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MEMBRANE PROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PERMEABILITY
PERTECHNETATES
PROTEINS
RADIOISOTOPES
RATS
REACTION KINETICS
RECEPTORS
REFRACTORY METAL COMPOUNDS
RODENTS
SODIUM COMPOUNDS
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES