Evaluation of the factors influencing the radiosensitivity of mouse ascites tumors

Journal Article · Mon Jan 31 23:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575984· OSTI ID:5993574

Okamoto, M; Tsuboi, A; Tsuchiya, T

Factors influencing the radiosensitivity of the newly established mouse ascites tumor TMT-3 line were studied. In vivo radiosensitivity of the tumor cells decreased with the progression of the growth phase in mice. Oxygen depletion was the major cause of the decreased radiosensitivity. Polarographic measurement of the oxygen dissolved in suspension of various cell densities suggested that high cell density such as in the ascites might well cause severe hypoxia. Humoral factors in the ascites and cell-to-cell contact had no effect on tumor cell radiosensitivity when the influence of the repair of potentially lethal damage was excluded.

• Research Organization: Department of Radiation Biology and Health, University of Environmental and Occupational Health, Yahatanishi-ku Kitakyushu, Japan
• OSTI ID: 5993574
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 93:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ASCITES TUMOR CELLS
EHRLICH ASCITES TUMOR
ELEMENTS
EXPERIMENTAL NEOPLASMS
IN VIVO
MAMMALS
MICE
NONMETALS
OXYGEN
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
TUMOR CELLS
VERTEBRATES