Evaluation of the factors influencing the radiosensitivity of mouse ascites tumors
Journal Article
·
· Radiat. Res.; (United States)
- Univ. of Environmental and Occupational Health, Yahatanishi-Ku Kitakyushu, Japan
Factors influencing the radiosensitivity of the newly established mouse ascites tumor TMT-3 line were studied. In vivo radiosensitivity of the tumor cells decreased with the progression of the growth phase in mice. Oxygen depletion was the major cause of the decreased radiosensitivity. Polarographic measurement of the oxygen dissolved in suspension of various cell densities suggested that high cell density such as in the ascites might well cause severe hypoxia. Humoral factors in the ascites and cell-to-cell contact had no effect on tumor cell radiosensitivity when the influence of the repair of potentially lethal damage was excluded.
- OSTI ID:
- 5741499
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 93:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ASCITES TUMOR CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DATA
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
EXPERIMENTAL DATA
INFORMATION
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
NONMETALS
NUMERICAL DATA
OXYGEN
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
RODENTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ASCITES TUMOR CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DATA
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
EXPERIMENTAL DATA
INFORMATION
IONIZING RADIATIONS
MAMMALS
MICE
NEOPLASMS
NONMETALS
NUMERICAL DATA
OXYGEN
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
RODENTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION