Cranial irradiation in acute leukemia: dose estimate in the lens. [Clinical and phantom dosimetry studies]

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)90049-X· OSTI ID:5986789

Kline, R W; Gillin, M T; Kun, L E

Cranial irradiation for subclinical arachnoid infiltration is standard treatment in childhood acute lymphocytic leukemia. The incidental dose received by the ocular lens is of potential importance since these children evidence a significant long-term survival rate. Comparison of the lens dose using 6MV and 4MV photon beams and a cobalt unit is presented in terms of ion chamber measurements in a water phantom and thermo-luminescent dosimetry (TLD) measurements in a head phantom. TLD measurements on patients treated for acute lymphocytic leukemia (ALL) are examined and used to estimate the dose to the lens. It is demonstrated that the dose to the lens depends strongly on the choice of field margin and on the daily patient set-up. However, using parallel opposed beams in a clinically determined optimal set-up, the dose to the lens is approximately 20 to 30% of the midline central axis dose. By angling the treatment head to eliminate the geometrical divergence of the beam, it is possible to reduce the lens dose to approximately 15% of the midline dose.

• Research Organization: Medical College of Wisconsin, Milwaukee
• OSTI ID: 5986789
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:1; ISSN IOBPD
• Country of Publication: United States
• Language: English

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550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CHILDREN
COBALT 60
COBALT ISOTOPES
CRYSTALLINE LENS
DATA
DATA FORMS
DEPTH DOSE DISTRIBUTIONS
DISEASES
DOSEMETERS
DOSES
DOSIMETRY
ELECTROMAGNETIC RADIATION
ENERGY RANGE
EXPERIMENTAL DATA
EYES
FRACTIONATED IRRADIATION
GAMMA DOSIMETRY
GAMMA RADIATION
GRAPHS
HEAD
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZATION CHAMBERS
IONIZING RADIATIONS
IRRADIATION
IRRADIATION PROCEDURES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
LOCAL IRRADIATION
LUMINESCENT DOSEMETERS
MAMMALS
MAN
MEASURING INSTRUMENTS
MEDICINE
MEV RANGE
MEV RANGE 01-10
MINUTES LIVING RADIOISOTOPES
MOCKUP
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PATIENTS
PHANTOMS
PRIMATES
RADIATION DETECTORS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIATION PROTECTION
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SIDE EFFECTS
SPATIAL DOSE DISTRIBUTIONS
STRUCTURAL MODELS
TABLES
THERAPY
THERMOLUMINESCENT DOSEMETERS
VERTEBRATES
X RADIATION
X-RAY DOSIMETRY
YEARS LIVING RADIOISOTOPES