The impact of cranial irradiation on the growth of children with acute lymphocytic leukemia

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Am. J. Dis. Child.; (United States)

DOI:https://doi.org/10.1001/archpedi.1983.02140270033012· OSTI ID:6326610

Wells, R J; Foster, M B; D'Ercole, A J; McMillan, C W

Heights, height velocities, weights, and weight velocities were measured serially in 21 patients with acute lymphocytic leukemia (ALL) who had survived three to five years in continuous complete remission. These patients were assigned randomly to treatment regimens that varied according to whether cranial irradiation was used. Patients receiving cranial irradiation had lower height velocities during therapy than normal subjects and patients not receiving cranial irradiation. Twenty-two other children with ALL, who were irradiated but not randomized, exhibited similar alterations in growth. These results indicate that cranial irradiation, and not leukemia or antileukemia chemotherapy, causes reduced growth.

• Research Organization: Department of Pediatrics, University of North Carolina, Chapel Hill
• OSTI ID: 6326610
• Journal Information: Am. J. Dis. Child.; (United States), Journal Name: Am. J. Dis. Child.; (United States) Vol. 137:1; ISSN AJDCA
• Country of Publication: United States
• Language: English

Related Subjects

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560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANIMAL GROWTH
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
CHILDREN
DIMENSIONS
DISEASES
GROWTH
HEIGHT
HEMIC DISEASES
IRRADIATION
LEUKEMIA
LOCAL IRRADIATION
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY