Effects of cranial radiation on hearing in children with acute lymphocytic leukemia
Journal Article
·
· J. Pediatr.; (United States)
The hearing sensitivity of 61 children with acute lymphocytic leukemia who were admitted to our Total Therapy IX study between December 1975 and July 1977 was studied. Their treatment included combined chemotherapy, 2400 rads of cranial radiation, and intrathecal methotrexate. Subjects initially received an otologic examination and middle ear function testing. Audiometric testing was not done until ears were free of outer or middle ear pathology. If the child had no outer or middle ear disease, audiometric thresholds were obtained for the test frequencies: 500, 1000, 2000, 4000, 6000, and 8000 Hz. Pure-tone thresholds were obtained before irradiation (61 patients) and at 6, 12, and 36 months thereafter (49, 46, and 22 patients, respectively). The median age of time of baseline testing was 10 years, 2 months. A paired sample test based on group data was used to test whether there were any significant changes from the threshold values at 6, 12, and 36 months after irradiation. Thresholds were not significantly affected for any test frequency at any test time. Assessments of individual audiograms indicated that none of the children had any significant reductions in hearing levels at the end of the third year after cranial irradiation.
- Research Organization:
- St. Jude Children's Research Hospital, Memphis, TN
- OSTI ID:
- 6314500
- Journal Information:
- J. Pediatr.; (United States), Journal Name: J. Pediatr.; (United States) Vol. 96:3; ISSN JOPDA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
AUDITORY ORGANS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHILDREN
COBALT
DISEASES
DYNAMIC FUNCTION STUDIES
ELEMENTS
HEAD
HEMIC DISEASES
INJURIES
IRRADIATION
LEUKEMIA
MEDICINE
METALS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SENSE ORGANS
SIDE EFFECTS
THERAPY
TRANSITION ELEMENTS
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
AUDITORY ORGANS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHILDREN
COBALT
DISEASES
DYNAMIC FUNCTION STUDIES
ELEMENTS
HEAD
HEMIC DISEASES
INJURIES
IRRADIATION
LEUKEMIA
MEDICINE
METALS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SENSE ORGANS
SIDE EFFECTS
THERAPY
TRANSITION ELEMENTS