Enhanced cis-platinum ototoxicity in children with brain tumours who have received simultaneous or prior cranial irradiation
Journal Article
·
· Med. Pediatr. Oncol.; (United States)
We report on four children who received cis-platinum simultaneously with, or in one case 10 months after, cranial irradiation and experienced exaggerated ototoxicity affecting all audible frequencies. The hearing loss was severe, affecting the critical areas for speech perception, and necessitated the provision of bilateral hearing aids. The audiograms of these patients are shown and compared to those of four children who had received cis-platinum as part of their treatment for neuroblastoma but without cranial irradiation. The precipitation of the exaggerated hearing loss with the administration of cis-platinum in one patient 10 months after finishing cranial irradiation suggests that care should be taken in the timing of cis-platinum administration in relation to concurrent or previous cranial irradiation.
- Research Organization:
- Royal Children's Hospital, Victoria (Australia)
- OSTI ID:
- 6469306
- Journal Information:
- Med. Pediatr. Oncol.; (United States), Journal Name: Med. Pediatr. Oncol.; (United States) Vol. 17:1; ISSN MPOND
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600* -- Medicine
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
AUDITORY ORGANS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHILDREN
COMBINED THERAPY
DISEASES
ELEMENTS
MEDICINE
METALS
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PLATINUM
PLATINUM METALS
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SENSITIVITY
THERAPY
TOXICITY
TRANSITION ELEMENTS
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
AUDITORY ORGANS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHILDREN
COMBINED THERAPY
DISEASES
ELEMENTS
MEDICINE
METALS
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PLATINUM
PLATINUM METALS
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SENSITIVITY
THERAPY
TOXICITY
TRANSITION ELEMENTS