Somnolence syndrome in leukemic children following reduced daily dose fractions of cranial radiation

Journal Article · Mon Oct 01 04:00:00 EDT 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90261-X· OSTI ID:6302513

Littman, P; Rosenstock, J; Gale, G; Krisch, R E; Meadows, A; Sather, H; Coccia, P; DeCamagro, B

A group of children with acute lymphocytic leukemia was studied to investigate if a reduction in daily dose fraction of cranial radiation would reduce the incidence of somnolence syndrome. Thirty-one evaluable patients received 100 rad x 18 cranial radiation therapy. Sixty-six similar evaluable patients were given 180 rad x 10. Both groups received the same chemotherapy including intrathecal methotrexate. Clinically detectable somnolence appeared in 58% of each group without significant differences in the overall frequency or severity of somnolence. This study failed to substantiate a radiation dose fraction size dependence for somnolence syndrome in children with acute lymphocytic leukemia.

• Research Organization: Univ. of Pennsylvania School of Medicine, Philadelphia
• OSTI ID: 6302513
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:10; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANTIMETABOLITES
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
DRUGS
FRACTIONATED IRRADIATION
HEMIC DISEASES
IRRADIATION
LEUKEMIA
MEDICINE
METHOTREXATE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY