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Glioblastoma multiforme following prophylactic cranial irradiation and intrathecal methotrexate in a child with acute lymphocytic leukemia. [. gamma. rays; infants]

Journal Article · · Cancer; (United States)
OSTI ID:6422156
; ; ; ;
Cases of radiation-induced glioma in humans are extremely rare. A 2-year-old boy with acute lymphocytic leukemia had received prophylactic cranial irradiation (2400 rad/2 1/2 weeks) and intrathecal methotrexate. Five years later he developed a glioblastoma multiforme on the left cerebral hemisphere while the leukemia was in remission. This is the first reported association of these disorders. It is possible that the glioma may have been induced by radiation and/or chemotherapy.
Research Organization:
Pennsylvania State Univ., Hershey
OSTI ID:
6422156
Journal Information:
Cancer; (United States), Journal Name: Cancer; (United States) Vol. 47:11; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
CHILDREN
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GLIOMAS
HEAD
HEMIC DISEASES
INFANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
LOCAL IRRADIATION
MEDICINE
METHOTREXATE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
THERAPY
YEARS LIVING RADIOISOTOPES