New tumor imaging agent--/sup 111/In-bleomycin complex. Comparison with /sup 67/Ga-citrate and /sup 57/Co-bleomycin in tumor-bearing animals

Journal Article · Wed Oct 31 23:00:00 EST 1984 · J. Surg. Oncol.; (United States)

DOI:https://doi.org/10.1002/jso.2930270313· OSTI ID:5969649

Hou, D Y; Hoch, H; Johnston, G S; Tsou, K C; Jones, A E; Miller, E E; Larson, S M

A new /sup 111/In-bleomycin complex (BLMC) has been found which has high affinity to tumor, does not bind to transferrin and is stable in vivo. Distribution in animals bearing glioma, hepatoma, or mammary adenocarcinoma at 48 hours showed: the ratios of tumor to blood, brain, heart, lung, liver, pancreas, stomach, and femur were 1.4-22.4 times as high for /sup 111/In-BLMC as for /sup 67/Ga-citrate. In mammary adenocarcinoma, /sup 111/In-BLMC bound more to viable and /sup 57/Co-Bleomycin (BLM) more to necrotic tumor. In viable tumor, the concentration of /sup 111/In-BLMC was similar to that of /sup 57/Co-BLM. The ratios of tumor to stomach and pancreas were higher, to blood, brain, muscle, heart, and femur were lower for /sup 111/In-BLMC than those for /sup 57/Co-BLM. The ratios of tumor to lung, liver, spleen, skin, and kidney were similar for the two compounds. Tumors were imaged more distinctly with the new /sup 111/In-BLMC and /sup 57/Co-BLM than with /sup 67/Ga-citrate. /sup 111/In-BLMC is promising for tumor imaging.

• Research Organization: National Inst. of Health, Bethesda, MD
• OSTI ID: 5969649
• Journal Information: J. Surg. Oncol.; (United States), Journal Name: J. Surg. Oncol.; (United States) Vol. 27:3; ISSN JSONA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BLEOMYCIN
BODY
COBALT 57
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
GLANDS
IMAGES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MAMMARY GLANDS
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION QUALITY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
VERTEBRATES