New /sup 111/In-bleomycin complex for combined radiotherapy and chemotherapy

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · J. Surg. Oncol.; (United States)

DOI:https://doi.org/10.1002/jso.2930290206· OSTI ID:5684730

Hou, D Y; Hoch, H; Johnston, G S; Tsou, K C; Jones, A E; Farkas, R J; Miller, E E; Larson, S M

Six days after tumor transplantation three daily intraperitoneal doses of 0.9% NaCl, bleomycin (BLM), or a new 111In-bleomycin complex (BLMC, 15 microCi/g body weight) were administered to glioma-bearing mice. After therapy, tumors in mice treated with /sup 111/In-BLMC were smaller than those treated with BLM. Sixteen days after the first injection tumor size for /sup 111/In-BLMC-treated mice was 560 (240-1,030) mm3, 1980 (1400-3290) mm3 for BLM (P less than 0.025), and 4830 (2580-9180) mm3 for NaCl (0.1 less than P less than 0.2). Thirteen days after tumor transplantation glioma-bearing mice received single intratumor injection of 0.9% NaCl, BLM, or /sup 111/In-BLMC (1.5 mCi, carried by 0.5 mg BLM/g tumor weight). The average tumor size for /sup 111/In-BLMC was smaller than that for BLM by a factor of 2.5-3.7. Host weights for these two groups were similar, and morphologic abnormalities were not found in kidney or liver.

• Research Organization: National Institutes of Health, Bethesda, MD
• OSTI ID: 5684730
• Journal Information: J. Surg. Oncol.; (United States), Journal Name: J. Surg. Oncol.; (United States) Vol. 2; ISSN JSONA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
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