Use of /sup 111/In-bleomycin for combining radiotherapy and chemotherapy on glioma-bearing mice

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · J. Surg. Oncol.; (United States)

DOI:https://doi.org/10.1002/jso.2930290202· OSTI ID:5802073

Hou, D Y; Hoch, H; Johnston, G S; Tsou, K C; Farkas, R J; Miller, E E

Mice bearing transplanted glioma received 0.9% NaCl, 0.1 mg of BLM, or 200-250 microCi of /sup 111/In-BLM (0.1 mg BLM) daily for 5 days intraperitoneally. After therapy, tumor sizes were in the order NaCl greater than BLM greater than /sup 111/In-BLM. On the 11th day after the first injection, tumor size (mm3) in the /sup 111/In-BLM group was 1220; in the BLM group, it was 2310 (P less than .025). After intratumor injection of a total dose of 0.1 mg of BLM/gm tumor weight, or of 1 mCi/gm tumor weight of /sup 111/In-BLM (carried by 0.1 mg of BLM/gm tumor weight), the tumor size decreased in the /sup 111/In-BLM group more than in the BLM group. On the 5th day after the 2nd dose therapy, the tumor size in the /sup 111/In-BLM group was 2020; in the BLM group it was 4220 (P less than .05). Host weights for these two groups were similar. The necrotic area in the tumor was much greater in the /sup 111/In-BLM group than in the BLM group. These results suggest the use for radiotherapy and chemotherapy.

• Research Organization: National Institutes of Health, Bethesda, MD
• OSTI ID: 5802073
• Journal Information: J. Surg. Oncol.; (United States), Journal Name: J. Surg. Oncol.; (United States) Vol. 2; ISSN JSONA
• Country of Publication: United States
• Language: English

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