Comparison between $sup 169$Yb-citrate and other tumor scanning agents (in Japanese)
The tumor affinity of /sup 169/Yb-citrate, /sup 67/Ga-citrate, /sup 111/ In-ci trate, and /sup 57/Co-bleomycin was examined by using Yoshida sarcomabearing rats, and inflammation affinity of these compounds was also tested by rats with inflammation induced by croton oil injection. In our experiments, / sup 111/In-citrate showed inferior value as the tumor scanning agent compared to / sup 67/Ga-citrate. /sup 67/Co-bleomycin had excellent biological characteristics as the tumor scanning agent, but physical half life of cobalt-57 is too long for this purpose. So it is desirable that bleomycin is labeled with the nuclide that has excellent properties for the medical use. All compounds except /sup 111/In- citrate had relatively strong affinity to the inflammation tissue. Values of the concentration ratio of these compounds between tumor and inflammatory tissue were 2.1 to 2.2 at 24 hrs after intravenous injection. The difference of their in vivo distri-bution between /sup 169/Yb-citrate, /sup 67/Ga-citrate, and /sup 111/ In-citrate was investigated in order to use these compounds more properly as the tumor scanning agent. In this investigation, there was no great difference of the uptake in the tumor tissue between these compounds. But great difference in the biological properties of these compounds was observed about the retention value in the blood and the uptake rate in the bone. /sup 169/Yb-citrate was rapidly cleared from the blood and was taken mostly in to the bone. So the retention values in the soft tissues became very small. On the other hand, /sup 111/In-citrate was slowly and slightly taken in to the bone from the blood, so the retention values in the soft tissues was remaining relatively high. /sup 67/ Ga-citrate showed the intermediate value of bone uptake rate between /sup 169/Yb- citrate and /sup 111/In-citrate. (auth)
- Research Organization:
- Kanazawa Univ., Japan
- NSA Number:
- NSA-29-024540
- OSTI ID:
- 4335730
- Journal Information:
- Radioisotopes (Tokyo), v. 22, no. 8, pp. 415-421, Journal Name: Radioisotopes (Tokyo), v. 22, no. 8, pp. 415-421; ISSN RAISA
- Country of Publication:
- Japan
- Language:
- Japanese
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