Uptake of the rare earth elements into tumors (in Japanese)
Journal Article
·
· Rinsho Hoshasen, v. 18, no. 3, pp. 188-190
OSTI ID:4384584
Mixtures of /sup 67/Ga-citrate and chlorides of rare earth elements, such as /sup 140/La, /sup 141/Ce, /sup 147/Nd, /sup 152/Eu, /sup 160/Tb and /sup 177/Lu, were injected intraperitoneally into a mouse implanted with Ehrlich carcinoma. Simultaneous measurement of the gamma spectrum in each organ was carried out after 48 hours by a Ge (Li) semiconductor detector, and the uptake of rare earth elements was compared with that of /sup 67/Ga. Judging from the whole- body autoradiograms of the mouse with Ehrlich carcinoma, the uptake of /sup 169/ Yb into the bone was greater than that of /sup 67/Ga, and it was more intensely incorporated in the bone tissue than in the marrow. Scintigrams of rats with Yoshida sarcoma also revealed that the uptake of /sup 169/Yb into tumors and the bones was great. Comparing the uptake of /sup 169/Yb into each organ with that of /sup 67/Ga, the latter was greatly incorporated into tumors, and the former into the bones and also in a great amount into the site of inflammation. In the clinical experience with /sup 169/Ybcitrate in lung cancer, the determination of tumor regions was difficult, because /sup 169/Yb-citrate was greatly incorporated into the sternum and the thoracic vertebrae, and the differential diagnosis between tumor and inflanamation was also difficult. /sup 67/Ga is clinically very useful for evaluation of the effects of radiotherapy. /sup 169/Yb has to be, however, treated with care, because of its long half-life, great uptake into the bones, and great exposure doses to the bones. (Japan)
- Research Organization:
- Kanagawa Dental Coll., Yokosuka, Japan
- NSA Number:
- NSA-29-013053
- OSTI ID:
- 4384584
- Journal Information:
- Rinsho Hoshasen, v. 18, no. 3, pp. 188-190, Journal Name: Rinsho Hoshasen, v. 18, no. 3, pp. 188-190; ISSN RHOSA
- Country of Publication:
- Japan
- Language:
- Japanese
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