Cell cycle dependent G2 delay and killing of L929 cells after exposure to /sup 241/Am. cap alpha. particles
Journal Article
·
· Radiat. Res.; (United States)
Survival and G2 delay of L929 mouse fibroblasts exposed to 3.4-MeV ..cap alpha.. particles depend on the cell age at the time of irradiation. Greatest sensitivity for both endpoints has been found at the G1/S transition: the surviving fraction of G1/S cells is reduced to 0.11 following 1 Gy of ..cap alpha.. particles compared to 0.31 for early G1 cells. The G2 + M transit time rises from 3 hr for control cells to 22 and 30 hr for cells irradiated with 0.3 Gy in G2 or at the G1/S boundary, respectively. Cells irradiated in early G1 do not show increased G2 + M transit times. Growth delay as calculated for the entire population increases linearly with dose by 23 hr/Gy of ..cap alpha.. particles.
- Research Organization:
- Kernforschungszentrum, Karlsruhe, West Germany
- OSTI ID:
- 5946760
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 100:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
AMERICIUM 241
AMERICIUM ISOTOPES
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BROMOURACILS
BUDR
CELL CYCLE
CELL FLOW SYSTEMS
CELL KILLING
CHARGED PARTICLES
CONNECTIVE TISSUE CELLS
DATA
DRUGS
EXPERIMENTAL DATA
FIBROBLASTS
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFORMATION
ISOTOPES
MAMMALS
MICE
MITOTIC DELAY
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RIBOSIDES
RODENTS
SOMATIC CELLS
URACILS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
AMERICIUM 241
AMERICIUM ISOTOPES
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BROMOURACILS
BUDR
CELL CYCLE
CELL FLOW SYSTEMS
CELL KILLING
CHARGED PARTICLES
CONNECTIVE TISSUE CELLS
DATA
DRUGS
EXPERIMENTAL DATA
FIBROBLASTS
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFORMATION
ISOTOPES
MAMMALS
MICE
MITOTIC DELAY
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RIBOSIDES
RODENTS
SOMATIC CELLS
URACILS
VERTEBRATES
YEARS LIVING RADIOISOTOPES