Comparison of several potential myocardial imaging agents

Conference · Tue Jan 01 04:00:00 EST 1985

OSTI ID:5941992

Watson, E E; Stabin, M G; Goodman, M M; Knapp, Jr, F F; Srivastava, P C

Although myocardial imaging is currently dominated by Tl-201, several alternative agents with improved physiologic or radionuclidic properties have been proposed. Based on human and animal studies in the literature, the metabolism of several of these compounds was studied for the purpose of generating radiation dose estimates. Dose estimates are listed for several I-123 labeled free fatty acids, an I-123 labeled phosphonium compound, Rb-82, Cu-64, F-18 FDG (all compounds which are taken up by the normal myocardium), and for Tc-99m pyrophosphate (PYP) (which localizes in myocardial infarcts). Dose estimates could not be generated for C-11 palmitate, but this compound was included in a comparison of myocardial retention times. For the I-123 labeled compounds, I-124 was included as a contaminant in generating the dose estimates. Radiation doses were lowest for Rb-82 (gonads 0.3 to 0.5 ..mu..Gy/MBq, heart wall 15 ..mu..Gy/MBq). Doses for the I-123 labeled fatty acids were similar to one another, with IPPA being the lowest (gonads 20 ..mu..Gy/MBq, heart wall 15 ..mu..Gy/MBq). Doses for Tc-99m PYP were also low (gonads 4 to 7 ..mu..Gy/MBq, heart wall 4 ..mu..Gy/MBq, skeleton 15 ..mu..Gy/MBq). The desirability of these compounds is discussed briefly, considering half life, imaging mode and energy, and dosimetry, including a comparison of the effective whole body dose equivalents. 34 refs., 11 tabs.

• Research Organization: Oak Ridge Associated Universities, Inc., TN (USA); Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400; AC05-76OR00033
• OSTI ID: 5941992
• Report Number(s): CONF-851113-6; ON: DE86008227
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL TISSUES
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLADDER
BODY
BONE MARROW
BRAIN
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
COPPER 64
COPPER ISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
FEMALE GENITALS
FLUORINE 18
FLUORINE ISOTOPES
FLUORODEOXYGLUCOSE
GLANDS
GONADS
HEART
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LIGHT NUCLEI
LIVER
LUNGS
MALE GENITALS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIUM
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OVARIES
PANCREAS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOISOTOPES
RESPIRATORY SYSTEM
RUBIDIUM 82
RUBIDIUM ISOTOPES
SPLEEN
TECHNETIUM 99
TECHNETIUM ISOTOPES
TESTES
TISSUE DISTRIBUTION
TISSUES
URINARY TRACT
YEARS LIVING RADIOISOTOPES