Assessment of radiation dose in nuclear cardiovascular imaging using realistic computational models

Journal Article · Mon Jun 15 04:00:00 EDT 2015 · Medical Physics

DOI:https://doi.org/10.1118/1.4921364· OSTI ID:22413590

Xie, Tianwu ^[1]; Lee, Choonsik ^[2]; Bolch, Wesley E. ^[3]; Zaidi, Habib ^[1]

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1. Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva 4 CH-1211 (Switzerland)
2. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20852 (United States)
3. Departments of Nuclear and Radiological and Biomedical Engineering, University of Florida, Gainesville, Florida 32611 (United States)

Purpose: Nuclear cardiology plays an important role in clinical assessment and has enormous impact on the management of a variety of cardiovascular diseases. Pediatric patients at different age groups are exposed to a spectrum of radiation dose levels and associated cancer risks different from those of adults in diagnostic nuclear medicine procedures. Therefore, comprehensive radiation dosimetry evaluations for commonly used myocardial perfusion imaging (MPI) and viability radiotracers in target population (children and adults) at different age groups are highly desired. Methods: Using Monte Carlo calculations and biological effects of ionizing radiation VII model, we calculate the S-values for a number of radionuclides (Tl-201, Tc-99m, I-123, C-11, N-13, O-15, F-18, and Rb-82) and estimate the absorbed dose and effective dose for 12 MPI radiotracers in computational models including the newborn, 1-, 5-, 10-, 15-yr-old, and adult male and female computational phantoms. Results: For most organs, {sup 201}Tl produces the highest absorbed dose whereas {sup 82}Rb and {sup 15}O-water produce the lowest absorbed dose. For the newborn baby and adult patient, the effective dose of {sup 82}Rb is 48% and 77% lower than that of {sup 99m}Tc-tetrofosmin (rest), respectively. Conclusions: {sup 82}Rb results in lower effective dose in adults compared to {sup 99m}Tc-labeled tracers. However, this advantage is less apparent in children. The produced dosimetric databases for various radiotracers used in cardiovascular imaging, using new generation of computational models, can be used for risk-benefit assessment of a spectrum of patient population in clinical nuclear cardiology practice.

• OSTI ID: 22413590
• Journal Information: Medical Physics, Journal Name: Medical Physics Journal Issue: 6 Vol. 42; ISSN 0094-2405; ISSN MPHYA6
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORBED RADIATION DOSES
ADULTS
BIOLOGICAL EFFECTS
CARBON 11
CARDIOVASCULAR DISEASES
FLUORINE 18
IODINE 123
MONTE CARLO METHOD
NEONATES
NITROGEN 13
OXYGEN 15
PATIENTS
PHANTOMS
RUBIDIUM 82
TECHNETIUM 99
THALLIUM 201
TRACER TECHNIQUES