Radiation dose estimates for a new myocardial perfusion agent: (E-1-(/sup 123/I)Iodo-1-Penten-5-yl)triphenylphosphonium iodide

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6611153

Stabin, M G; Watson, E E; Coffey, J L; Srivastava, P C; Knapp, Jr, F F

Phosphonium cations labeled with gamma-emitting radionuclides have been suggested as myocardial perfusion agents, since these cations penetrate the hydrophobic core of the myocardial cell membrane. A model agent, (E-I-Iodo-I-Penten-5-y1) triphenylphosphonium iodide labeled with /sup 123/I in the 1 position, shows rapid myocardial extraction and high heart:blood and heart:liver ratios in female Fischer rats. Detailed distribution studies were performed for the purpose of extrapolating radiation dose estimates for humans. Myocardial uptake in humans, estimated from rat data, would be about 4.5% of the injected activity and would have a biological half-time of 52 hours. The doses to the heart and total body would be 0.027 mGy/MBq (0.10 rad/mCi) and 0.011 mGy/MBq (0.041 rad/mCi), respectively. The doses to the kidneys and thyroid would be 0.027 mGy/MBq (0.10 rad/mCi) and 0.37 mGy/MBq (1.4 rad/mCi), respectively. The doses to other organs, including the ovaries, would not exceed 0.012 mGy/MBq (0.043 rad/mCi). These estimates indicate that the radiation doses for this new agent are within acceptable limits for human use.

• Research Organization: Oak Ridge Associated Universities (ORAU), Oak Ridge, TN
• DOE Contract Number: AC05-76OR00033
• OSTI ID: 6611153
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
DISTRIBUTION
DOSES
DOSIMETRY
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HALIDES
HALOGEN COMPOUNDS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODIDES
IODINE 123
IODINE COMPOUNDS
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHOSPHORUS COMPOUNDS
PHOSPHORUS IODIDES
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES