((E)-1-( STI)Iodo-1-penten-5-yl)triphenylphosphonium iodide: convenient preparation of a potentially useful myocardial perfusion agent
Journal Article
·
· J. Med. Chem.; (United States)
A rapid iodination method has been developed for the synthesis of the new STI-labeled phosphonium cation ((E)-1-iodo-1-penten-5-yl)triphenylphosphonium iodide by I treatment of the corresponding trans-vinylboronic acid. This new model myocardial perfusion agent is obtained after purification in 25-50% yield in <1 h. High myocardial uptake (5 min, 2.38% dose/g) with prolonged retention (3 h, 2.21% dose/g) was observed in rats. In addition, heart/blood ratios were high and continued to increase over a 1-day period (5 min, 17:1; 60 min, 23:1; 3 h, 27:1, 1 day, 158:1). In rats, the liver uptake was moderate (5 min, 1.40% dose/g; 60 min; 0.25% dose/g). Excellent myocardial images were obtained in a dog. 22 references, 1 figure, 2 tables.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6233542
- Journal Information:
- J. Med. Chem.; (United States), Journal Name: J. Med. Chem.; (United States) Vol. 27:8; ISSN JMCMA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radiation dose estimates for a new myocardial perfusion agent: (E-1-(/sup 123/I)Iodo-1-Penten-5-yl)triphenylphosphonium iodide
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Modification of lypophilic groups and replacement of phosphorus by arsenic to study the effect on myocardial specificity of radioiodinated phosphonium cations
Conference
·
Sat Dec 31 23:00:00 EST 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:6611153
New myocardial imaging agents: stabilization of radioiodine as a terminal vinyl iodide moiety on tellurium fatty acids
Journal Article
·
Thu Sep 01 00:00:00 EDT 1983
· J. Med. Chem.; (United States)
·
OSTI ID:5656158
Modification of lypophilic groups and replacement of phosphorus by arsenic to study the effect on myocardial specificity of radioiodinated phosphonium cations
Conference
·
Sat Dec 31 23:00:00 EST 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:6590991
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
DATA
DIGESTIVE SYSTEM
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
GLANDS
HALOGENATION
HEART
HOURS LIVING RADIOISOTOPES
IMAGES
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINATION
IODINE 123
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PERFUSED TISSUES
RADIOISOTOPES
RATS
RODENTS
TISSUES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
DATA
DIGESTIVE SYSTEM
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
GLANDS
HALOGENATION
HEART
HOURS LIVING RADIOISOTOPES
IMAGES
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINATION
IODINE 123
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PERFUSED TISSUES
RADIOISOTOPES
RATS
RODENTS
TISSUES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES