Enkephalin, dynorphin and substance P in postmortem substantia nigra from normals and schizophrenic patients
- National Institute of Dental Research, Bethesda, MD (USA) National Institute of Mental Health, Washington, DC (USA)
Three peptide neuromodulators that are found in high concentration in the subtantia nigra: dynorphin A 1,8-met5-enkephalin-arg6-gly7-leu8 and substance P, were measured by specific radioimmunoassays in nigral tissue from normals and schizophrenics postmortem. Substance P and dynorphin were unchanged between the two groups. However, the proenkephalin-derived peptide was significantly elevated in the schizophrenic group. The immunoreactivity was identified as authentic met5-enkephalin-arg6-gly7-leu8 by high pressure liquid chromatography. The data suggest that a different set of regulatory controls exists for nigral enkephalin peptides as compared to dynorphin and substance P, and that the former system may be disordered in schizophrenia.
- OSTI ID:
- 5941716
- Journal Information:
- Life Sciences; (USA), Vol. 48:20; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
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550901* - Pathology- Tracer Techniques