Enkephalin, dynorphin and substance P in postmortem substantia nigra from normals and schizophrenic patients

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90224-Y· OSTI ID:5941716

Iadarola, M J; Ofri, D; Kleinman, J E ^[1]

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1. National Institute of Dental Research, Bethesda, MD (USA) National Institute of Mental Health, Washington, DC (USA)

Three peptide neuromodulators that are found in high concentration in the subtantia nigra: dynorphin A 1,8-met5-enkephalin-arg6-gly7-leu8 and substance P, were measured by specific radioimmunoassays in nigral tissue from normals and schizophrenics postmortem. Substance P and dynorphin were unchanged between the two groups. However, the proenkephalin-derived peptide was significantly elevated in the schizophrenic group. The immunoreactivity was identified as authentic met5-enkephalin-arg6-gly7-leu8 by high pressure liquid chromatography. The data suggest that a different set of regulatory controls exists for nigral enkephalin peptides as compared to dynorphin and substance P, and that the former system may be disordered in schizophrenia.

• OSTI ID: 5941716
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 48:20; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOASSAY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHROMATOGRAPHY
COMPARATIVE EVALUATIONS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ENDORPHINS
ENKEPHALINS
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MAN
MENTAL DISORDERS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
SEPARATION PROCESSES
TRACER TECHNIQUES
VERTEBRATES