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Quantitation of phosphorus excretion in sheep by compartmental analysis

Journal Article · · Am. J. Physiol.; (United States)
OSTI ID:5928639

The control of phosphorus excretion in sheep has been examined by constructing a kinetic model that contains a mechanistic set of connections between blood and gastrointestinal tract. The model was developed using experimental data from chaff-fed sheep and gives an accurate description of the absorption and excretion of /sup 32/P phosphorus in feces and urine of the ruminating sheep. These results indicated the main control site for phosphorus excretion in the ruminating sheep was the gastrointestinal tract, whereas for the non-ruminating sheep fed the liquid diet, control was exerted by the kidney. A critical factor in the induction of adaptation of phosphorus reabsorption by the kidney was the reduction in salivation, and since this response occurred independently of marked changes in the delivery of phosphorus to the kidney, a humoral factor may be involved in this communication between salivary gland and kidney.

Research Organization:
La Trobe Univ., Bundoora, Australia
OSTI ID:
5928639
Journal Information:
Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:4; ISSN AJPHA
Country of Publication:
United States
Language:
English