Kinetic model of whole-body vanadium metabolism: studies in sheep
A compartmental model for vanadium metabolism in sheep has been proposed. The model is consistent with data obtained from sheep fed a control diet (2.6 ppm vanadium) containing 0 or 200 ppm supplemental vanadium. Sheep were administered UYV dioxovanadium either orally or intravenously. Blood feces, and urine radioactivity were monitored for 6 days postdosing. Several new insights regarding vanadium metabolism are suggested and tested against the data using the model. Some of these include 1) significant absorption of UYV occurs from the upper gastrointestinal tract; 2) an in vivo process is necessary in order for UYV dioxovanadium to be converted into a more biologically reactive species; 3) at steady state the upper and lower gastrointestinal tracts contain at least 10- and 100-fold more mass of vanadium, respectively, than does blood. No statistically significant differences in transport rate constants were found between animals receiving 0 and 200 ppm supplemental dietary vanadium. The availability of a model will enable the refinement of future studies regarding vanadium metabolism in the ruminant.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 6414243
- Journal Information:
- Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 251:2; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD CHEMISTRY
CHALCOGENIDES
COMPARTMENTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTRAVENOUS INJECTION
ISOTOPES
MAMMALS
MATHEMATICAL MODELS
NUCLEI
ODD-ODD NUCLEI
ORAL ADMINISTRATION
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RUMINANTS
SCINTILLATION COUNTING
SHEEP
TRANSITION ELEMENT COMPOUNDS
UPTAKE
VANADIUM 48
VANADIUM COMPOUNDS
VANADIUM ISOTOPES
VANADIUM OXIDES
VERTEBRATES