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Occupational history and involvement of chromosomes 5 and 7 in acute nonlymphocytic leukemia

Journal Article · · Cancer Genet. Cytogenet.; (United States)
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We compared the histories of exposure to leukemogens for two groups of patients presenting with myelodysplastic syndrome (MDS) or acute nonlymphocytic leukemia (ANLL). In one group there were 59 patients with an acquired abnormality of chromosomes 5 or 7 in the marrow at time of diagnosis. In the other group there were 39 patients with a normal marrow karyotype at the time of diagnosis. A much higher proportion of the chromosomally abnormal cases had a history of treatment for a previous malignancy (odds ratio = 13.0, p less than 0.01). There was little difference found between the occupational histories of the patients with de novo ANLL with and without cytogenetic abnormalities. An occupational history of exposure to chemicals or metals was more common in males with either a deletion of the long arm of chromosome 7 or with monosomy 7 or monosomy 5 (82.3%) than in males with a normal karyotype (52.1%). The odds ratios did not, however, reach statistical significance. 37 references.
Research Organization:
Hospital for Sick Children, Toronto, Ontario (Canada)
OSTI ID:
5925538
Journal Information:
Cancer Genet. Cytogenet.; (United States), Journal Name: Cancer Genet. Cytogenet.; (United States) Vol. 38:2; ISSN CGCYD
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
CARCINOGENESIS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DISEASES
DOCUMENT TYPES
ELEMENTS
GENETIC EFFECTS
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
KARYOTYPE
LEUKEMIA
METALS
MUTATIONS
NEOPLASMS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PATHOGENESIS
PATIENTS
REVIEWS
TOXICITY
XENOBIOTICS