Environmental exposures in cytogenetically defined subsets of acute nonlymphocytic leukemia

Journal Article · Fri Aug 04 04:00:00 EDT 1989 · JAMA, J. Am. Med. Assoc.; (United States)

DOI:https://doi.org/10.1001/jama.262.5.634· OSTI ID:5596187

Crane, M M; Keating, M J; Trujillo, J M; Labarthe, D R; Frankowski, R F

Three previous investigations have reported a relationship between clonal chromosome abnormalities in marrow of patients with acute nonlymphocytic leukemia and employment in occupations involving mutagenic chemicals, but the effects of other exposures were not described. Environmental exposure profiles, gathered by questionnaire, were therefore compared using a case-control study design in 235 newly diagnosed patients with acute nonlymphocytic leukemia: 126 with abnormal and 109 with normal karyotypes. The univariate odds ratio for occupation at diagnosis was 4.6, which, when adjusted for demographic and other exposures by logistic regression, was reduced to 2.5 (95% confidence interval, 0.5 to 12.8). Adjusted point estimates for other exposures were 4.3 (1.4 to 13.3) for prior cytotoxic therapy, 1.7 (0.9 to 3.1) for cigarette smoking, and 1.9 (1.0 to 3.4) for alcohol use. Dose-response relationships were present for both tobacco and alcohol consumption. Associations between specific abnormalities (plus8, -7I-7Q, inv16, t(8;21)) and certain exposures were also present. These results suggest that life-style exposures may be associated with cytogenetic lesions in persons with acute nonlymphocytic leukemia.

• Research Organization: Univ. of Texas School of Public Health, Houston (USA)
• OSTI ID: 5596187
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Journal Name: JAMA, J. Am. Med. Assoc.; (United States) Vol. 262:5; ISSN JAMAA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
CHROMOSOMAL ABERRATIONS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ENVIRONMENTAL EXPOSURE
EPIDEMIOLOGY
ETHANOL
HEMIC DISEASES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
KARYOTYPE
LEUKEMIA
MAMMALS
MAN
MUTAGENESIS
MUTATIONS
NEOPLASMS
ORGANIC COMPOUNDS
PATIENTS
PRIMATES
TOXICITY
VERTEBRATES
XENOBIOTICS