Cytogenetic, clinical, and cytologic characteristics of radiotherapy-related leukemias

Journal Article · Fri Apr 01 04:00:00 EST 1988 · Cancer Genet. Cytogenet.; (United States)

DOI:https://doi.org/10.1016/0165-4608(88)90221-X· OSTI ID:6997843

Philip, P; Pedersen-Bjergaard, J

From 1978 to 1985, we observed eight cases of acute nonlymphocytic leukemia or preleukemia, three cases of acute lymphoblastic leukemia, and three cases of chronic myeloid leukemia in patients previously treated exclusively with radiotherapy for other tumor types. The latent period from administration of radiotherapy to development of leukemia varied between 12 and 243 months. Clonal chromosome aberrations reported previously as characteristic of acute nonlymphocytic leukemia following therapy with alkylating agents were observed in three of the eight patients with acute nonlymphocytic leukemia (5q- and -7) and in two of the three patients with acute lymphoblastic leukemia (-7 and 12p-). All three patients with radiotherapy-related chronic myeloid leukemia presented a t(9;22)(q34;q11). The results suggest that cytogenetic characteristics may reflect the etiology in radiation-induced acute leukemias, whereas radiation-related chronic myeloid leukemia does not seem to differ chromosomally from de novo cases of the disease.

• Research Organization: Finsen Institute-Rigshospitalet, Copenhagen (Denmark)
• OSTI ID: 6997843
• Journal Information: Cancer Genet. Cytogenet.; (United States), Journal Name: Cancer Genet. Cytogenet.; (United States) Vol. 31:2; ISSN CGCYD
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMAL ABERRATIONS
DELAYED RADIATION EFFECTS
DISEASES
ETIOLOGY
HEMIC DISEASES
LEUKEMIA
MEDICINE
MUTATIONS
MYELOID LEUKEMIA
NEOPLASMS
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY